Diverse control mechanisms of the interleukin-1 cytokine family
The majority of interleukin-1 (IL-1) family cytokines lack amino terminal secretion signals or
transmembrane domains for secretion along the conventional biosynthetic pathway. Yet …
transmembrane domains for secretion along the conventional biosynthetic pathway. Yet …
How pyroptosis contributes to inflammation and fibroblast-macrophage cross-talk in rheumatoid arthritis
About thirty years ago, a new form of pro-inflammatory lytic cell death was observed and
termed pyroptosis. Only in 2015, gasdermins were defined as molecules that create pores at …
termed pyroptosis. Only in 2015, gasdermins were defined as molecules that create pores at …
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6
K Tsujimoto, T Jo, D Nagira, H Konaka, JH Park… - The EMBO …, 2023 - embopress.org
The cellular activation of the NLRP3 inflammasome is spatiotemporally orchestrated by
various organelles, but whether lysosomes contribute to this process remains unclear. Here …
various organelles, but whether lysosomes contribute to this process remains unclear. Here …
Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology
Some of the current and former organizers of the Cold Spring Harbor Laboratory
(CSHL)'Gene Expression and Signaling in the Immune System'(GESIS) meeting offer …
(CSHL)'Gene Expression and Signaling in the Immune System'(GESIS) meeting offer …
Biting the hand that feeds: Metabolic determinants of cell fate during infection
Metabolic shifts can occur in cells of the innate immune system in response to microbial
infection. Whether these metabolic shifts benefit host defense and propagation of an …
infection. Whether these metabolic shifts benefit host defense and propagation of an …