Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Many biological events, such as the propagation of nerve impulses, the synchronized cell
cycles of early embryogenesis, and collective cell migration, must be coordinated with …

Many cells can generate complementary traveling waves of actin filaments (F-actin) and
cytoskeletal regulators. This phenomenon, termed cortical excitability, results from coupled …

Cells come in a variety of shapes that most often underlie their functions. Regulation of cell
morphogenesis implies that there are mechanisms for shape sensing that still remain poorly …

Immune cells, such as macrophages and dendritic cells, can utilize podosomes,
mechanosensitive actin-rich protrusions, to generate forces, migrate, and patrol for foreign …

The actomyosin cortex is an active material that generates force to drive shape changes via
cytoskeletal remodeling. Cytokinesis is the essential cell division event during which a …

While rhythmic contractile behavior is commonly observed at the cellular cortex, the primary
focus has been on excitable or periodic events described by simple activator-delayed …

As the interface between the cell and its environment, the cell cortex must be able to
respond to a variety of external stimuli. This is made possible in part by cortical excitability, a …

Interest in cortical excitability—the ability of the cell cortex to generate traveling waves of
protein activity—has grown considerably over the past 20 years. Attributing biological …

The reaction-diffusion waves of proteins are known to be involved in fundamental cellular
functions, such as cell migration, cell division, and vesicular transportation. In some of these …