Ribonucleotide reductases: structure, chemistry, and metabolism suggest new therapeutic targets
Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …
deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing …
Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705−762
JA Stubbe, WA van Der Donk - Chemical reviews, 1998 - ACS Publications
Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705−762 | Chemical Reviews ACS
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …
ACS Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …
Dioxygen activation by enzymes containing binuclear non-heme iron clusters
BJ Wallar, JD Lipscomb - Chemical Reviews, 1996 - ACS Publications
Dioxygen activation by metalloenzymes generally proceeds through one of two
fundamentally different routes. Some enzymes, such as the ferric ion containing intradiol …
fundamentally different routes. Some enzymes, such as the ferric ion containing intradiol …
Radical initiation in the class I ribonucleotide reductase: long-range proton-coupled electron transfer?
JA Stubbe, DG Nocera, CS Yee, MCY Chang - Chemical reviews, 2003 - ACS Publications
Ribonucleotide reductases (RNRs) catalyze the conversion of nucleotides to
deoxynucleotides in all organisms (eq 1). 1-3 These enzymes play an essential role in DNA …
deoxynucleotides in all organisms (eq 1). 1-3 These enzymes play an essential role in DNA …
Ribonucleotide reductases
A Jordan, P Reichard - Annual review of biochemistry, 1998 - annualreviews.org
Ribonucleotide reductases provide the building blocks for DNA replication in all living cells.
Three different classes of enzymes use protein free radicals to activate the substrate …
Three different classes of enzymes use protein free radicals to activate the substrate …
Proton-coupled electron transfer in biology: results from synergistic studies in natural and model systems
SY Reece, DG Nocera - Annual review of biochemistry, 2009 - annualreviews.org
Proton-coupled electron transfer (PCET) underpins energy conversion in biology. PCET may
occur with the unidirectional or bidirectional transfer of a proton and electron and may …
occur with the unidirectional or bidirectional transfer of a proton and electron and may …
Structure, function, and mechanism of ribonucleotide reductases
Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …
ribonucleotides to 2′-deoxyribonucleotides and thereby provides the precursors needed …
Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase
EC Minnihan, DG Nocera… - Accounts of chemical …, 2013 - ACS Publications
Ribonucleotide reductases (RNRs) catalyze the conversionof nucleotides to 2′-
deoxynucleotides and are classified on the basis of the metallo-cofactor used to conduct this …
deoxynucleotides and are classified on the basis of the metallo-cofactor used to conduct this …
Structure of ribonucleotide reductase protein R1
U Uhlin, H Eklund - Nature, 1994 - nature.com
Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribo-
nucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves …
nucleotides and is thus a key enzyme in DNA synthesis. The radical-based reaction involves …
Proton-coupled electron flow in protein redox machines
JL Dempsey, JR Winkler, HB Gray - Chemical reviews, 2010 - ACS Publications
Electron transfer (ET) reactions are fundamental steps in biological redox processes.
Respiration is a case in point: at least 15 ET reactions are required to take reducing …
Respiration is a case in point: at least 15 ET reactions are required to take reducing …