Study of tree shrew biology and models: A booming and prosperous field for biomedical research

YG Yao, L Lu, RJ Ni, R Bi, C Chen… - Zoological …, 2024 - pmc.ncbi.nlm.nih.gov
The tree shrew (Tupaia belangeri) has long been proposed as a suitable alternative to non-
human primates (NHPs) in biomedical and laboratory research due to its close evolutionary …

Connecto-informatics at the mesoscale: current advances in image processing and analysis for map** the brain connectivity

YK Choi, L Feng, WK Jeong, J Kim - Brain Informatics, 2024 - Springer
Map** neural connections within the brain has been a fundamental goal in neuroscience
to understand better its functions and changes that follow aging and diseases …

The interhemispheric amygdala-accumbens circuit encodes negative valence in mice

Z Tian, J Song, X Zhao, Y Zhou, X Chen, Q Le, F Wang… - Science, 2024 - science.org
The structurally symmetric mammalian brain hemispheres are interconnected by
commissural axons across the midline. However, the functions of interhemispheric …

Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory

JF Watson, V Vargas-Barroso, RJ Morse-Mora… - Cell, 2025 - cell.com
Our brain has remarkable computational power, generating sophisticated behaviors, storing
memories over an individual's lifetime, and producing higher cognitive functions. However …

Massive multiplexing of spatially resolved single neuron projections with axonal BARseq

L Yuan, X Chen, H Zhan, GL Henry… - Nature Communications, 2024 - nature.com
Neurons in the cortex are heterogeneous, sending diverse axonal projections to multiple
brain regions. Unraveling the logic of these projections requires single-neuron resolution …

Dorsoventral heterogeneity of synaptic connectivity in hippocampal CA3 pyramidal neurons

M Li, YQ Jiang, DK Lee, H Wang, MC Lu… - Journal of …, 2024 - jneurosci.org
The hippocampal CA3 region plays an important role in learning and memory. CA3
pyramidal neurons (PNs) receive two prominent excitatory inputs—mossy fibers (MFs) from …

Neuronal diversity and stereotypy at multiple scales through whole brain morphometry

Y Liu, S Jiang, Y Li, S Zhao, Z Yun, ZH Zhao… - Nature …, 2024 - nature.com
We conducted a large-scale whole-brain morphometry study by analyzing 3.7 peta-voxels of
mouse brain images at the single-cell resolution, producing one of the largest multi …

Anatomical topology of extrahippocampal projections from dorsoventral CA pyramidal neurons in mice

J Lee, J Park, M Jeong, SJ Oh, JH Yoon… - Frontiers in …, 2024 - frontiersin.org
The hippocampus primarily functions through a canonical trisynaptic circuit, comprised of
dentate granule cells and CA1-CA3 pyramidal neurons (PNs), which exhibit significant …

Optical sectioning methods in three-dimensional bioimaging

J Zhang, W Qiao, R **, H Li, H Gong… - Light: Science & …, 2025 - nature.com
In recent advancements in life sciences, optical microscopy has played a crucial role in
acquiring high-quality three-dimensional structural and functional information. However, the …

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

JR Thompson, ED Nelson, M Tippani, AD Ramnauth… - BioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
The hippocampus contains many unique cell types, which serve the structure's specialized
functions, including learning, memory and cognition. These cells have distinct spatial …