The aim of this ESC Guideline is to help health professionals manage people with heart
failure (HF) according to the best available evidence. Fortunately, we now have a wealth of …

Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Abstract Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator)(Netherlands),
P. Christian Schulze (CPG Review Coordinator)(Germany), Magdy Abdelhamid (Egypt) …

Importance Frailty is a common geriatric syndrome of significant public health importance,
yet there is limited understanding of the risk of frailty development at a population level …

“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Background: Frailty may modify the risk− benefit profile of certain treatments, and frail
patients may have reduced tolerance to treatments. Objective: To investigate the efficacy of …

Aim Depression and frailty are prevalent and burdensome in older age. However, the
relationships between these entities are unclear and no quantitative meta-analysis exists …

Background: Frailty is increasing in prevalence. Because patients with frailty are often
perceived to have a less favorable risk/benefit profile, they may be less likely to receive new …

Introduction Frailty is one of the most important concerns regarding our aging population.
Evidence grows that the syndrome is linked to several important health outcomes. A general …

Background Frailty is a geriatric syndrome that affects multiple domains of human
functioning. A variety of problems contributes to the development of this syndrome; poor …