Hepatocellular Carcinoma (HCC) is one of the most common types of primary liver cancer.
Current treatment options have limited efficacy against this malignancy, primarily owing to …

Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a
variety of illnesses, and its popularity is increasing worldwide. However, the clinical …

Cuproptosis caused by copper overload is mediated by a novel regulatory mechanism that
differs from previously documented mechanisms regulating cell death. Cells dependent on …

Abstract N6-methyladenosine (m6A) RNA modification is the most common and conserved
epigenetic modification in mRNA and has been shown to play important roles in cancer …

Chemotherapeutic efficacy is seriously impeded by chemoresistance in more than half of
hepatocellular carcinoma (HCC) patients. However, the mechanisms involved in …

Objective Hepatocellular carcinoma (HCC) poses a significant clinical challenge because
the long-term benefits of immune checkpoint blockade therapy are limited. A comprehensive …

Aims Therapeutic outcome of sorafenib in hepatocellular carcinoma (HCC) is undermined
by the development of drug resistance. This study aimed to identify the critical microRNA …

Background and aims Hepatocellular carcinoma (HCC) is one of the most common
malignancies in the world and the sixth leading cause of cancer death worldwide, and it is …

For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle
hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important …

The natural product auraptene can influence tumor cell proliferation and invasion, but its
effect on hepatocellular carcinoma (HCC) cells is unknown. Here, we report that auraptene …