The mechanical properties of cells and tissues help determine their architecture,
composition and function. Alterations to these properties are associated with many diseases …

Tissue engineering has produced innovative tools for cancer research. 3D cancer models
based on molecularly designed biomaterials aim to harness the dimensionality and …

Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes
in extracellular matrix (ECM) mechanics contribute to cancer development,, and increased …

Cell migration on two-dimensional substrates is typically characterized by lamellipodia at the
leading edge, mature focal adhesions and spread morphologies. These observations result …

Experimental in vitro models that capture pathophysiological characteristics of human
tumours are essential for basic and translational cancer biology. Here, we describe a fully …

The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Hyaluronic acid (HA)‐based biomaterials have been explored for a number of applications
in biomedical engineering, particularly as tissue regeneration scaffolds. Crosslinked forms of …

Simple Summary This review depicts the principal mechanisms involved in the process of
stromal desmoplasia characterizing pancreatic ductal adenocarcinoma (PDAC). The aim of …

The extracellular matrix (ECM) mechanical properties regulate key cellular processes in
tissue development and regeneration. The majority of scientific investigation has focused on …

In tumor engineering, 3D approaches are used to model components of the tumor
microenvironment and to test new treatments. Pancreatic cancers are a cancer of substantial …