Carbohydrate-active enzymes (CAZymes) in the gut microbiome

JF Wardman, RK Bains, P Rahfeld… - Nature Reviews …, 2022 - nature.com
The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

Roles of intestinal Parabacteroides in human health and diseases

Y Cui, L Zhang, X Wang, Y Yi, Y Shan… - FEMS microbiology …, 2022 - academic.oup.com
The stability of gut microbiota is essential for the host's health. Parabacteroides spp., core
members of the human gut microbiota, have an average abundance of 1.27% in humans of …

dbCAN3: automated carbohydrate-active enzyme and substrate annotation

J Zheng, Q Ge, Y Yan, X Zhang, L Huang… - Nucleic Acids …, 2023 - academic.oup.com
Carbohydrate active enzymes (CAZymes) are made by various organisms for complex
carbohydrate metabolism. Genome mining of CAZymes has become a routine data analysis …

dbCAN2: a meta server for automated carbohydrate-active enzyme annotation

H Zhang, T Yohe, L Huang, S Entwistle… - Nucleic acids …, 2018 - academic.oup.com
Complex carbohydrates of plants are the main food sources of animals and microbes, and
serve as promising renewable feedstock for biofuel and biomaterial production …

Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

R Seshadri, SC Leahy, GT Attwood, KH Teh… - Nature …, 2018 - nature.com
Productivity of ruminant livestock depends on the rumen microbiota, which ferment
indigestible plant polysaccharides into nutrients used for growth. Understanding the …

Polysaccharide degradation by the Bacteroidetes: mechanisms and nomenclature

LS McKee, SL La Rosa, B Westereng… - Environmental …, 2021 - Wiley Online Library
The Bacteroidetes phylum is renowned for its ability to degrade a wide range of complex
carbohydrates, a trait that has enabled its dominance in many diverse environments. The …

Bacteroidetes use thousands of enzyme combinations to break down glycans

P Lapébie, V Lombard, E Drula, N Terrapon… - Nature …, 2019 - nature.com
Unlike proteins, glycan chains are not directly encoded by DNA, but by the specificity of the
enzymes that assemble them. Theoretical calculations have proposed an astronomical …

Prevotella: A key player in ruminal metabolism

CL Betancur-Murillo, SB Aguilar-Marín, J Jovel - Microorganisms, 2022 - mdpi.com
Ruminants are foregut fermenters that have the remarkable ability of converting plant
polymers that are indigestible to humans into assimilable comestibles like meat and milk …

[HTML][HTML] Interspecies competition impacts targeted manipulation of human gut bacteria by fiber-derived glycans

ML Patnode, ZW Beller, ND Han, J Cheng, SL Peters… - Cell, 2019 - cell.com
Development of microbiota-directed foods (MDFs) that selectively increase the abundance
of beneficial human gut microbes, and their expressed functions, requires knowledge of both …

Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease

E Hayase, T Hayase, MA Jamal, T Miyama, CC Chang… - Cell, 2022 - cell.com
The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD),
which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT) …