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Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …
The transcriptional and epigenetic landscape of cancer cell lineage plasticity
Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …
molecular and/or histologic identity, is a key driver of cancer progression and therapy …
Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect
Radiation therapy is a mainstay of cancer treatment but does not always lead to complete
tumor regression. Here we combine radiotherapy with blockade of the 'don't-eat-me'cell …
tumor regression. Here we combine radiotherapy with blockade of the 'don't-eat-me'cell …
IL-18–secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models
Patients with small cell lung cancer (SCLC) generally have a poor prognosis and a median
overall survival of only about 13 months, indicating the urgent need for novel therapies …
overall survival of only about 13 months, indicating the urgent need for novel therapies …
TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer
H Lv, Q Zong, C Chen, G Lv, W **ang, F **ng… - Nature …, 2024 - nature.com
Induction of tumor vascular normalization is a crucial measure to enhance immunotherapy
efficacy. cGAS-STING pathway is vital for anti-tumor immunity, but its role in tumor …
efficacy. cGAS-STING pathway is vital for anti-tumor immunity, but its role in tumor …
H3K27me3 conditions chemotolerance in triple-negative breast cancer
The persistence of cancer cells resistant to therapy remains a major clinical challenge. In
triple-negative breast cancer, resistance to chemotherapy results in the highest recurrence …
triple-negative breast cancer, resistance to chemotherapy results in the highest recurrence …
STING activation promotes robust immune response and NK cell–mediated tumor regression in glioblastoma models
Immunotherapy has had a tremendous impact on cancer treatment in the past decade, with
hitherto unseen responses at advanced and metastatic stages of the disease. However, the …
hitherto unseen responses at advanced and metastatic stages of the disease. However, the …
[HTML][HTML] The role of stem cells in small-cell lung cancer: evidence from chemoresistance to immunotherapy
W Guo, T Qiao, T Li - Seminars in cancer biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, accounting for
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …
Mutant IDH inhibits IFNγ–TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
Abstract Isocitrate dehydrogenase 1 mutations (mIDH1) are common in
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1,
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …