The subcommittee reviewed the prevalence, incidence, risk factors, natural history, morbidity
and questionnaires reported in epidemiological studies of dry eye disease (DED). A meta …

Geographic atrophy (GA) is an advanced form of age-related macular degeneration (AMD)
that leads to progressive and irreversible loss of visual function. Geographic atrophy is …

Background CEP290-associated inherited retinal degeneration causes severe early-onset
vision loss due to pathogenic variants in CEP290. EDIT-101 is a clustered regularly …

The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-
START (recruited between 1997 and 2001) and SHIP-TREND (recruited between 2008 to …

REVERSE is a randomized, double-masked, sham-controlled, multicenter, phase 3 clinical
trial that evaluated the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects …

Background Primary angle-closure glaucoma is a leading cause of irreversible blindness
worldwide. In early-stage disease, intraocular pressure is raised without visual loss …

Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized
by the degeneration of rod photoreceptors, followed by the degeneration of cone …

Background Since they were first derived more than three decades ago, embryonic stem
cells have been proposed as a source of replacement cells in regenerative medicine, but …

Purpose To compare the anatomic and functional efficacy and safety of half-dose
photodynamic therapy (PDT) versus high-density subthreshold micropulse laser (HSML) …

Purpose To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects
with visual loss from Leber hereditary optic neuropathy (LHON). Design RESCUE is a …