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RNA structure probing uncovers RNA structure-dependent biological functions
RNA molecules fold into complex structures that enable their diverse functions in cells.
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …
From structure to function: Route to understanding lncRNA mechanism
J Graf, M Kretz - BioEssays, 2020 - Wiley Online Library
RNAs have emerged as a major target for diagnostics and therapeutics approaches.
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Signaling by LncRNAs: Structure, cellular homeostasis, and disease pathology
The cellular signaling network involves co-ordinated regulation of numerous signaling
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …
The molecular structure of long non-coding RNAs: emerging patterns and functional implications
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …
cellular processes and are crucially connected to diseases. Despite their unprecedented …
Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery
In recent years, researchers have identified certain RNAs as druggable targets for small
molecules to treat several human pathologies. However, these regulatory RNAs are …
molecules to treat several human pathologies. However, these regulatory RNAs are …
RNA sample optimization for cryo-EM analysis
RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …
structures of RNAs primarily determine their functions, it remains challenging to …
Noncoding RNAs: biology and applications—a Keystone Symposia report
The human transcriptome contains many types of noncoding RNAs, which rival the number
of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 …
of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 …
Advances, Applications, and Perspectives in Small‐Angle X‐ray Scattering of RNA
JN Tants, A Schlundt - Chembiochem, 2023 - Wiley Online Library
RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …
iDRiP for the systematic discovery of proteins bound directly to noncoding RNA
HP Chu, A Minajigi, Y Chen, R Morris, CY Guh… - Nature protocols, 2021 - nature.com
More than 90% of the human genome is transcribed into noncoding RNAs, but their
functional characterization has lagged behind. A major bottleneck in the understanding of …
functional characterization has lagged behind. A major bottleneck in the understanding of …
Advances in understanding the role of lncRNA in ferroptosis
Y Wen, W Lei, J Zhang, Q Liu, Z Li - PeerJ, 2024 - peerj.com
LncRNA is a type of transcript with a length exceeding 200 nucleotides, which was once
considered junk transcript with no biological function during the transcription process. In …
considered junk transcript with no biological function during the transcription process. In …