RNA structure probing uncovers RNA structure-dependent biological functions

XW Wang, CX Liu, LL Chen, QC Zhang - Nature chemical biology, 2021 - nature.com
RNA molecules fold into complex structures that enable their diverse functions in cells.
Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells …

From structure to function: Route to understanding lncRNA mechanism

J Graf, M Kretz - BioEssays, 2020 - Wiley Online Library
RNAs have emerged as a major target for diagnostics and therapeutics approaches.
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …

Signaling by LncRNAs: Structure, cellular homeostasis, and disease pathology

R Nadhan, C Isidoro, YS Song, DN Dhanasekaran - Cells, 2022 - mdpi.com
The cellular signaling network involves co-ordinated regulation of numerous signaling
molecules that aid the maintenance of cellular as well as organismal homeostasis. Aberrant …

The molecular structure of long non-coding RNAs: emerging patterns and functional implications

I Chillón, M Marcia - Critical Reviews in Biochemistry and Molecular …, 2020 - Taylor & Francis
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …

Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery

J Manigrasso, M Marcia, M De Vivo - Chem, 2021 - cell.com
In recent years, researchers have identified certain RNAs as druggable targets for small
molecules to treat several human pathologies. However, these regulatory RNAs are …

RNA sample optimization for cryo-EM analysis

X Chen, L Wang, J **e, JS Nowak, B Luo, C Zhang… - Nature …, 2024 - nature.com
RNAs play critical roles in most biological processes. Although the three-dimensional (3D)
structures of RNAs primarily determine their functions, it remains challenging to …

Noncoding RNAs: biology and applications—a Keystone Symposia report

J Cable, E Heard, T Hirose, KV Prasanth… - Annals of the new …, 2021 - Wiley Online Library
The human transcriptome contains many types of noncoding RNAs, which rival the number
of protein‐coding species. From long noncoding RNAs (lncRNAs) that are over 200 …

Advances, Applications, and Perspectives in Small‐Angle X‐ray Scattering of RNA

JN Tants, A Schlundt - Chembiochem, 2023 - Wiley Online Library
RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

iDRiP for the systematic discovery of proteins bound directly to noncoding RNA

HP Chu, A Minajigi, Y Chen, R Morris, CY Guh… - Nature protocols, 2021 - nature.com
More than 90% of the human genome is transcribed into noncoding RNAs, but their
functional characterization has lagged behind. A major bottleneck in the understanding of …

Advances in understanding the role of lncRNA in ferroptosis

Y Wen, W Lei, J Zhang, Q Liu, Z Li - PeerJ, 2024 - peerj.com
LncRNA is a type of transcript with a length exceeding 200 nucleotides, which was once
considered junk transcript with no biological function during the transcription process. In …