Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM)
and this appears to underlie the development of cardiovascular disease, T2DM and diabetic …

For the past 40years or so, oxidative stress has been increasingly recognized as a
contributing factor in aging and in various forms of pathophysiology generally associated …

Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee
beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

Preeclampsia (PE) has a profound effect in increasing both maternal and fetal morbidity and
mortality especially in third World. Disturbances of extravillous trophoblast migration toward …