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Cortico-basal ganglia plasticity in motor learning
One key function of the brain is to control our body's movements, allowing us to interact with
the world around us. Yet, many motor behaviors are not innate but require learning through …
the world around us. Yet, many motor behaviors are not innate but require learning through …
The human motor cortex microcircuit: insights for neurodegenerative disease
The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …
BASS: multi-scale and multi-sample analysis enables accurate cell type clustering and spatial domain detection in spatial transcriptomic studies
Spatial transcriptomic studies are reaching single-cell spatial resolution, with data often
collected from multiple tissue sections. Here, we present a computational method, BASS …
collected from multiple tissue sections. Here, we present a computational method, BASS …
Dendritic spine plasticity: function and mechanisms
Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
by Ramón y Cajal using his famous Golgi stainings. Around 50 years later the advance of …
Learning binds new inputs into functional synaptic clusters via spinogenesis
Learning induces the formation of new excitatory synapses in the form of dendritic spines,
but their functional properties remain unknown. Here, using longitudinal in vivo two-photon …
but their functional properties remain unknown. Here, using longitudinal in vivo two-photon …
[HTML][HTML] Xenotransplanted human cortical neurons reveal species-specific development and functional integration into mouse visual circuits
How neural circuits develop in the human brain has remained almost impossible to study at
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …
the neuronal level. Here, we investigate human cortical neuron development, plasticity, and …
[HTML][HTML] Synaptic modifications in learning and memory–a dendritic spine story
Synapses are specialized sites where neurons connect and communicate with each other.
Activity-dependent modification of synaptic structure and function provides a mechanism for …
Activity-dependent modification of synaptic structure and function provides a mechanism for …
[HTML][HTML] Neuronal plasticity and age-related functional decline in the motor cortex
Physiological aging causes a decline of motor function due to impairment of motor cortex
function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty …
function, losses of motor neurons and neuromuscular junctions, sarcopenia, and frailty …
Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with …
Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the
pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the …
pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the …
Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia-and addiction-relevant features: The RHA vs. RLA rats
Abstract The Roman High-(RHA) and Low-(RLA) avoidance rat lines/strains were generated
through bidirectional selective breeding for rapid (RHA) vs. extremely poor (RLA) two-way …
through bidirectional selective breeding for rapid (RHA) vs. extremely poor (RLA) two-way …