Abstract MRI with hyperpolarized (HP) 13C agents, also known as HP 13C MRI, can
measure processes such as localized metabolism that is altered in numerous cancers, liver …

Non-invasive 13C magnetic resonance spectroscopy measurements of the uptake and
subsequent metabolism of 13C-labeled substrates is a powerful method for studying …

First described in 2003, the dissolution dynamic nuclear polarization (DNP) technique,
combined with 13 C magnetic resonance spectroscopy (MRS), has since been used in …

MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to
provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this …

Real-time detection of the rates of metabolic flux, or exchange rates of endogenous
enzymatic reactions, is now feasible in biological systems using Dynamic Nuclear …

Gain-of-function mutations of the isocitrate dehydrogenase 1 (IDH1) gene are among the
most prevalent in low-grade gliomas and secondary glioblastoma. They lead to intracellular …

Dissolution dynamic nuclear polarization (DNP) enables the metabolism of hyperpolarized
13C‐labelled molecules, such as the conversion of [1‐13C] pyruvate to [1‐13C] lactate, to …

Abstract Hyperpolarized [1-13C]-pyruvate has shown tremendous promise as an agent for
imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging …

New magnetic resonance (MR) molecular imaging techniques offer the potential for
noninvasive, simultaneous quantification of metabolic and perfusion parameters in tumors …

Based on the expanding set of applications for hyperpolarized carbon‐13 (HP‐13C) MRI,
this work aims to communicate standardized methodology implemented at the University of …