Omics approaches to discover pathophysiological pathways contributing to human pain
There exist limited data to inform mechanism-based understanding and management of
chronic pain, and thus, there is a clear unmet need to better define the molecular …
chronic pain, and thus, there is a clear unmet need to better define the molecular …
[HTML][HTML] Fibromyalgia patients with elevated levels of anti–satellite glia cell immunoglobulin G antibodies present with more severe symptoms
Transferring fibromyalgia patient immunoglobulin G (IgG) to mice induces pain-like
behaviour, and fibromyalgia IgG binds mouse and human satellite glia cells (SGCs). These …
behaviour, and fibromyalgia IgG binds mouse and human satellite glia cells (SGCs). These …
A Comprehensive review of the genetic and epigenetic contributions to the development of fibromyalgia
EA Ovrom, KA Mostert, S Khakhkhar, DP McKee… - Biomedicines, 2023 - mdpi.com
This narrative review summarizes the current knowledge of the genetic and epigenetic
contributions to the development of fibromyalgia (FM). Although there is no single gene that …
contributions to the development of fibromyalgia (FM). Although there is no single gene that …
The therapeutic potential of natural killer cells in neuropathic pain
Novel disease-modifying treatments for neuropathic pain are urgently required. The cellular
immune response to nerve injury represents a promising target for therapeutic development …
immune response to nerve injury represents a promising target for therapeutic development …
Long COVID and the neuroendocrinology of microbial translocation outside the GI tract: some treatment strategies
Similar to previous pandemics, COVID-19 has been succeeded by well-documented post-
infectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and …
infectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and …
miR-374 family is a key regulator of chronic primary pain onset
Objectives: We sought to identify RNA species correlated with case status in 3 pain cohorts,
to validate RNAs found to be dysregulated in a mouse model of CPPC onset, and to directly …
to validate RNAs found to be dysregulated in a mouse model of CPPC onset, and to directly …
Finding new analgesics: Computational pharmacology faces drug discovery challenges
Despite the worldwide prevalence and huge burden of pain, pain is an undertreated
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
Distinct CholinomiR blood cell signature as a potential modulator of the cholinergic system in women with fibromyalgia syndrome
Fibromyalgia syndrome (FMS) is a heterogeneous chronic pain syndrome characterized by
musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood …
musculoskeletal pain and other key co-morbidities including fatigue and a depressed mood …
A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with …
Background Low dose naltrexone (LDN) is used off-label by many individuals with
fibromyalgia to help manage their pain. There is no current systematic literature review …
fibromyalgia to help manage their pain. There is no current systematic literature review …