Highlights•Toxoplasma gondii evokes a strong innate and adaptive immune response in the
host.•Innate immunity to the parasite is comprised of many components like DC, neutrophils …

Toxoplasma gondii is a widespread parasitic pathogen that infects over a third of the world's
population. Following an acute infection, the parasite can persist within its mammalian host …

During chronic infection and cancer, a self-renewing CD8+ T cell subset maintains long-term
immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8+ T cells …

Selected CD8+ T cells must divide, produce differentiated effector cells, and self-renew,
often repeatedly. We now show that silencing expression of the transcription factor TCF1 …

Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced
murine CD8+ T cells that retain potential for lymphoid recirculation and the ability to self …

The identification of T-bet as a key transcription factor associated with the development of
IFNγ-producing CD4+ T cells predicted a crucial role for T-bet in cell-mediated immunity and …

Salmonella enterica (Se) bacteria cause persistent intracellular infections while stimulating a
robust interferon-γ-producing CD4+ T (Th1) cell response. We addressed this paradox of …

The ability of Toxoplasma gondii to inject the rhoptry kinase ROP16 into host cells results in
the activation of the transcription factors STAT3 and STAT6, but it is unclear how these …

The discovery of meningeal lymphatic vessels that drain the CNS has prompted new
insights into how immune responses develop in the brain. In this study, we examined how T …

Recent data indicate that the differentiation state of Th1 cells determines their protective
capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in …