Microglia and beyond: innate immune cells as regulators of brain development and behavioral function

KM Lenz, LH Nelson - Frontiers in immunology, 2018 - frontiersin.org
Innate immune cells play a well-documented role in the etiology and disease course of
many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic …

Cell death by phagocytosis

GC Brown - Nature Reviews Immunology, 2024 - nature.com
Cells can die as a consequence of being phagocytosed by other cells—a form of cell death
that has been called phagotrophy, cell cannibalism, programmed cell removal and primary …

Transcriptional and translational differences of microglia from male and female brains

D Guneykaya, A Ivanov, DP Hernandez, V Haage… - Cell reports, 2018 - cell.com
Sex differences in brain structure and function are of substantial scientific interest because of
sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a …

Microglia in Alzheimer disease: well-known targets and new opportunities

AL Hemonnot, J Hua, L Ulmann… - Frontiers in aging …, 2019 - frontiersin.org
Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Uncovering sex differences of rodent microglia

J Han, Y Fan, K Zhou, K Blomgren… - Journal of …, 2021 - Springer
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …

A tool for map** microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

G Colombo, RJA Cubero, L Kanari, A Venturino… - Nature …, 2022 - nature.com
Environmental cues influence the highly dynamic morphology of microglia. Strategies to
characterize these changes usually involve user-selected morphometric features, which …

Plasticity of microglia

M Augusto‐Oliveira, GP Arrifano, CI Delage… - Biological …, 2022 - Wiley Online Library
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

Microglia as dynamic cellular mediators of brain function

EC Wright-**, DH Gutmann - Trends in Molecular Medicine, 2019 - cell.com
Originally hypothesized to function solely as immunologic responders within the central
nervous system (CNS), emerging evidence has revealed that microglia have more complex …

Phagocytic astrocytes: Emerging from the shadows of microglia

H Konishi, S Koizumi, H Kiyama - Glia, 2022 - Wiley Online Library
Elimination of dead or live cells take place in both a healthy and diseased central nervous
system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance …

Microglia‐dependent remodeling of neuronal circuits

JR Guedes, PA Ferreira, JM Costa… - Journal of …, 2022 - Wiley Online Library
Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal
support, and immune defense of the brain parenchyma. Recently, the role played by …