The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over
50 human disorders, including Alzheimer's and Parkinson's diseases. Increasing evidence …

Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …

Translation is pervasive outside of canonical coding regions, occurring in long noncoding
RNAs, canonical untranslated regions and introns,,–, especially in ageing …

Motivation Protein solubility is an important property in industrial and therapeutic
applications. Prediction is a challenge, despite a growing understanding of the relevant …

The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …

INTRODUCTION Temperature is crucially important to life. Small temperature changes can
differentiate optimal and lethal growth conditions of living organisms. Because of the higher …

Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

Disruption of mitochondrial function and protein homeostasis plays a central role in aging.
However, how these processes interact and what governs their failure in aging remain …

While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and
chromium, is undisputed, the underlying molecular mechanisms are not entirely clear …