Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …

Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In
some cases, mutated cancer genes are potent biomarkers for responses to targeted agents …

The aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function
is not completely understood. We find that EWS-FLI1 reprograms gene regulatory circuits in …

Alterations in transcriptional regulators can orchestrate oncogenic gene expression
programs in cancer. Here, we show that the BRG1/BRM-associated factor (BAF) chromatin …

Chromosome aberrations, in particular translocations and their corresponding gene fusions,
have an important role in the initial steps of tumorigenesis; at present, 358 gene fusions …

Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by
specific fusions between EWS and ETS genes, is highly debated. Through gene expression …

Osteosarcoma is a disease with many complex genetic abnormalities but few well defined
genetic drivers of tumor initiation and evolution. The disease is diagnosed and defined …

Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute
a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma …