Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …

Like other forms of engineering, metabolic engineering requires knowledge of the
components (the 'parts list') of the target system. Lack of such knowledge impairs both …

Metabolic networks are regulated to ensure the dynamic adaptation of biochemical reaction
fluxes to maintain cell homeostasis and optimal metabolic fitness in response to …

Genome-based Flux Balance Analysis (FBA) and steady-state isotopic-labeling-based
Metabolic Flux Analysis (MFA) are complimentary approaches to predicting and measuring …

Random mutagenesis and selection approaches used traditionally for the development of
industrial strains have largely been complemented by metabolic engineering, which allows …

The development of continuous culture techniques 60 years ago and the subsequent
formulation of theory and the diversification of experimental systems revolutionised …

Background Ralstonia eutropha H16, found in both soil and water, is a Gram-negative
lithoautotrophic bacterium that can utillize CO 2 and H 2 as its sources of carbon and energy …

Streptomycetes are industrially and pharmaceutically important bacteria that produce a
variety of secondary metabolites including antibiotics. Streptomycetes have a complex …

The insect cells/baculovirus system is well recognized as a safe and suitable technology to
produce heterologous proteins, vaccines and vectors for gene therapy. Efficient and robust …

Driven by advancements in high‐throughput biological technologies and the growing
number of sequenced genomes, the construction of in silico models at the genome scale …