Ligand recognition and G-protein coupling of trace amine receptor TAAR1
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …
essential roles in neurological and metabolic homeostasis. They recognize diverse …
Recognition of methamphetamine and other amines by trace amine receptor TAAR1
Trace amine-associated receptor 1 (TAAR1), the founding member of a nine-member family
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …
Unlocking the therapeutic potential of ulotaront as a trace amine-associated receptor 1 agonist for neuropsychiatric disorders
All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-
associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several …
associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several …
Irisin stimulates protective signaling pathways in rat hippocampal neurons
Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and
alleviates memory impairment in Alzheimer's disease (AD). Irisin is an exercise-linked …
alleviates memory impairment in Alzheimer's disease (AD). Irisin is an exercise-linked …
Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice
Stress management is necessary for vertebrate survival. Chronic stress drives depression by
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …
Trace amine signaling in zebrafish models: CNS pharmacology, behavioral regulation and translational relevance
DS Galstyan, NA Krotova, AS Lebedev… - European Journal of …, 2025 - Elsevier
Tyramine, β-phenylethylamine, octopamine and other trace amines are endogenous
substances recently recognized as important novel neurotransmitters in the brain. Trace …
substances recently recognized as important novel neurotransmitters in the brain. Trace …
Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays
E Cichero, V Francesconi, B Casini, M Casale… - Pharmaceuticals, 2023 - mdpi.com
Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of
innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible …
innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible …
Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats
IS Zhukov, Y Alnefeesi, NA Krotova, VV Nemets… - Frontiers in …, 2024 - frontiersin.org
Introduction Aggression and self-harm disproportionately occur in youths preoccupied with
social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit …
social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit …
[HTML][HTML] Simultaneous mass spectrometric quantification of trace amines, their precursors and metabolites
K de Bruyn, EF Diekman, CP van der Ley… - … of Chromatography B, 2024 - Elsevier
Objectives Trace amines are powerful neuromodulators influencing the release and
reuptake of catecholamines. These low concentrated endogenous amines impact mood …
reuptake of catecholamines. These low concentrated endogenous amines impact mood …
Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet
SA Apryatin, IS Zhukov, EA Zolotoverkhaya… - Neurology …, 2023 - mdpi.com
Trace amines and their receptors are a family of G protein-coupled receptors widely
distributed in the central nervous system and periphery. The trace amine-associated …
distributed in the central nervous system and periphery. The trace amine-associated …