Ligand recognition and G-protein coupling of trace amine receptor TAAR1

Z Xu, L Guo, J Yu, S Shen, C Wu, W Zhang, C Zhao… - Nature, 2023 - nature.com
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …

Recognition of methamphetamine and other amines by trace amine receptor TAAR1

H Liu, Y Zheng, Y Wang, Y Wang, X He, P Xu, S Huang… - Nature, 2023 - nature.com
Trace amine-associated receptor 1 (TAAR1), the founding member of a nine-member family
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …

Unlocking the therapeutic potential of ulotaront as a trace amine-associated receptor 1 agonist for neuropsychiatric disorders

SR Kuvarzin, I Sukhanov, K Onokhin, K Zakharov… - Biomedicines, 2023 - mdpi.com
All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-
associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several …

Irisin stimulates protective signaling pathways in rat hippocampal neurons

MV Lourenco, GB de Freitas, Í Raony… - Frontiers in Cellular …, 2022 - frontiersin.org
Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and
alleviates memory impairment in Alzheimer's disease (AD). Irisin is an exercise-linked …

Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice

SH Yang, E Yang, J Lee, JY Kim, H Yoo… - Nature …, 2023 - nature.com
Stress management is necessary for vertebrate survival. Chronic stress drives depression by
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …

Trace amine signaling in zebrafish models: CNS pharmacology, behavioral regulation and translational relevance

DS Galstyan, NA Krotova, AS Lebedev… - European Journal of …, 2025 - Elsevier
Tyramine, β-phenylethylamine, octopamine and other trace amines are endogenous
substances recently recognized as important novel neurotransmitters in the brain. Trace …

Discovery of Guanfacine as a Novel TAAR1 Agonist: A Combination Strategy through Molecular Modeling Studies and Biological Assays

E Cichero, V Francesconi, B Casini, M Casale… - Pharmaceuticals, 2023 - mdpi.com
Trace amine-associated receptor 1 (TAAR1) is an attractive target for the design of
innovative drugs to be applied in diverse pharmacological settings. Due to a non-negligible …

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats

IS Zhukov, Y Alnefeesi, NA Krotova, VV Nemets… - Frontiers in …, 2024 - frontiersin.org
Introduction Aggression and self-harm disproportionately occur in youths preoccupied with
social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit …

[HTML][HTML] Simultaneous mass spectrometric quantification of trace amines, their precursors and metabolites

K de Bruyn, EF Diekman, CP van der Ley… - … of Chromatography B, 2024 - Elsevier
Objectives Trace amines are powerful neuromodulators influencing the release and
reuptake of catecholamines. These low concentrated endogenous amines impact mood …

Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet

SA Apryatin, IS Zhukov, EA Zolotoverkhaya… - Neurology …, 2023 - mdpi.com
Trace amines and their receptors are a family of G protein-coupled receptors widely
distributed in the central nervous system and periphery. The trace amine-associated …