Transient receptor potential cation channels in disease

B Nilius, G Owsianik, T Voets… - Physiological …, 2007 - journals.physiology.org
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

[HTML][HTML] Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum

L Lemoine, P Sugarbaker… - World journal of …, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes …

[HTML][HTML] TRP channels in disease

B Nilius - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2007 - Elsevier
“Transient receptor potential” cation channels (TRP channels) play a unique role as cell
sensors, are involved in a plethora of Ca2+-mediated cell functions, and play a role as “gate …

The cell biology of polycystic kidney disease

HC Chapin, MJ Caplan - Journal of Cell Biology, 2010 - rupress.org
Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

TRPP2 and TRPV4 form a polymodal sensory channel complex

M Köttgen, B Buchholz, MA Garcia-Gonzalez… - The Journal of cell …, 2008 - rupress.org
The primary cilium has evolved as a multifunctional cellular compartment that decorates
most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular …

[書籍][B] Mammalian transient receptor potential (TRP) cation channels

B Nilius, V Flockerzi - 2014 - Springer
When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression

Z **ao, S Zhang, J Mahlios, G Zhou… - Journal of Biological …, 2006 - ASBMB
We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a
transmembrane protein that is a component of the polycystin-2 (PC2)-ciliary mechano …

TRP channels: a TR (I) P through a world of multifunctional cation channels

B Nilius, T Voets - Pflügers Archiv, 2005 - Springer
The “transient receptor potential”(TRP) family of ion channels comprises more than 50 cation-
permeable channels expressed from yeast to man. On the basis of structural homology, the …

Transient receptor potential channelopathies

B Nilius, G Owsianik - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
In the past years, several hereditary diseases caused by defects in transient receptor
potential channels (TRP) genes have been described. This review summarizes our current …

[書籍][B] TRP ion channel function in sensory transduction and cellular signaling cascades

WB Liedtke - 2006 - taylorfrancis.com
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …