Significance: Oxidative stress is considered to be an important component of various
diseases. A vast number of methods have been developed and used in virtually all diseases …

S-nitrosylation, the covalent attachment of a nitrogen monoxide group to the thiol side chain
of cysteine, has emerged as an important mechanism for dynamic, post-translational …

An increasing number of reports indicate that endogenously produced inhibitors of nitric
oxide synthase, particularly asymmetric dimethylarginine (ADMA), regulate nitric oxide …

Objective—Plasma levels of an endogenous nitric oxide (NO) synthase inhibitor, asymmetric
dimethylarginine (ADMA), are elevated in chronic renal failure, hypertension, and chronic …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

Elevated plasma concentrations of the endogenous nitric oxide synthase (eNOS) inhibitor
asymmetric dimethylarginine (ADMA) represent a novel risk factor for the development of …

There is abundant evidence that the endothelium plays a crucial role in the maintenance of
vascular tone and structure. One of the major endothelium-derived vasoactive mediators is …

temic vascular resistance by approximately 24% in healthy human subjects. 23 Elevated
plasma levels of ADMA are predictive of the increased renovascular resistance observed …

Many cardiovascular diseases and drug-induced complications are associated with-or even
based on-an imbalance between the formation of reactive oxygen and nitrogen species …