The importance of radical-induced damage to DNA is apparent from the ever-increasing
number of publications in this area. This review focuses on the damage caused to DNA by …

In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …

As researchers begin probing deep coverage sequencing data for increasingly rare
mutations and subclonal events, the fidelity of next generation sequencing (NGS) laboratory …

Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …

The principal oxidized cytosine bases, uracil glycol, 5-hydroxycytosine, and 5-hydroxyuracil,
are readily bypassed, miscode, and are thus important premutagenic lesions. Similarly the …

Oxidative DNA damage has been implicated in mutagenesis, carcinogenesis and aging.
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen …

Deoxyribonucleic acid (DNA) appears to be a critical cellular target for the biological effects
(cellular lethality, mutagenesis, carcinogenesis, and ageing) of oxidation processes …

DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis
utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped …

The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic
product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and …

Cellular DNA is continually damaged by a plethora of extrinsic and intrinsic sources,
including UV light from the sun and reactive oxygen species resulting from aerobic …