Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …

Telomere shortening to a critical length can trigger aging and shorter life spans in mice and
humans by a mechanism that involves induction of a persistent DNA damage response at …

Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …

Evolutionary biology and biomedicine have seen a surge of recent interest in the possibility
that telomeres play a role in life-history trade-offs and ageing. Here, I evaluate alternative …

Various biological attributes associated with individual fitness in animals change predictably
over the lifespan of an organism. Therefore, the study of animal ecology and the work of …

Individual differences in telomere length have been linked to survival and senescence.
Understanding the heritability of telomere length can provide important insight into individual …

The prediction that telomere length (TL) shortens with increasing age is a major element in
considering the role of telomeres as a key player in evolution. While telomere attrition is …

Telomeres are highly conserved regions of DNA that protect the ends of linear
chromosomes. The loss of telomeres can signal an irreversible change to a cell's state …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …