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Towards an understanding of psychedelic-induced neuroplasticity
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …
[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …
[HTML][HTML] REBUS and the anarchic brain: toward a unified model of the brain action of psychedelics
This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …
History repeating: guidelines to address common problems in psychedelic science
Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …
Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials
Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …
with a growing number of clinical studies examining a wide range of conditions and …
Psychedelics promote structural and functional neural plasticity
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of
depression and related disorders. The ability to promote both structural and functional …
depression and related disorders. The ability to promote both structural and functional …
Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function
The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …
regarding human research with classic psychedelics (classic hallucinogens), which are …
Quality of acute psychedelic experience predicts therapeutic efficacy of psilocybin for treatment-resistant depression
Introduction: It is a basic principle of the “psychedelic” treatment model that the quality of the
acute experience mediates long-term improvements in mental health. In the present paper …
acute experience mediates long-term improvements in mental health. In the present paper …
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial
BackgroundRecent open-label trials show that psychedelics, such as ayahuasca, hold
promise as fast-onset antidepressants in treatment-resistant depression. MethodsTo test the …
promise as fast-onset antidepressants in treatment-resistant depression. MethodsTo test the …
Psychedelics
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter
perception and mood and affect numerous cognitive processes. They are generally …
perception and mood and affect numerous cognitive processes. They are generally …