The mammalian retina provides an excellent opportunity to study glia–neuron interactions
and the interactions of glia with blood vessels. Three main types of glial cells are found in …

Due to their permanent and close proximity to neurons, glial cells perform essential tasks for
the normal physiology of the retina. Astrocytes and Müller cells (retinal macroglia) provide …

Background Glaucomatous optic neuropathy, a leading cause of blindness, can progress
despite control of intraocular pressure-currently the main risk factor and target for treatment …

Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative
disease characterized by an irreversible decrease in ganglion cells and their axons …

Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …

Purpose: To analyze the long-term effect of optic nerve injury on retinal ganglion cells
(RGCs) and melanopsin+ RGCs orthotopic and displaced, and on the rest of the ganglion …

Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

In clinical glaucoma, as well as in experimental models, the loss of retinal ganglion cells
occurs by apoptosis. This final event is preceded by inflammatory responses involving the …

Purpose.: To assess the effect of a single intravitreal injection of brain-derived neurotrophic
factor (BDNF) on the survival of mouse retinal ganglion cells (RGCs) and on phagocytic …

Although the immune system functions to preserve and restore tissue homeostasis,
accumulating risk factors, prolonged glial activation, and sustained release of pro …