Communities of microorganisms (microbiota) are present in all habitats on Earth and are
relevant for agriculture, health, and climate. Deciphering the mechanisms that determine …

An increasing number of industrial bioprocesses capitalize on living cells by using them as
cell factories that convert sugars into chemicals. These processes range from the production …

Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as
bystanders in the drama of biological systems. The emerging field of lipidomics is driven by …

In metabolism research, thermodynamics is usually used to determine the directionality of a
reaction or the feasibility of a pathway. However, the relationship between thermodynamic …

Kinetic models are critical to predict the dynamic behaviour of metabolic networks.
Mechanistic kinetic models for large networks remain uncommon due to the difficulty of fitting …

Kinetic models of metabolism relate metabolic fluxes, metabolite concentrations and enzyme
levels through mechanistic relations, rendering them essential for understanding, predicting …

Cofactors are involved in numerous intracellular reactions and critically influence redox
balance and cellular metabolism. Cofactor engineering can support and promote the …

In contrast to stoichiometric-based models, the development of large-scale kinetic models of
metabolism has been hindered by the challenge of identifying kinetic parameter values and …

Phytochemicals are of great pharmaceutical and agricultural importance, but often exhibit
low abundance in nature. Recent demonstrations of industrial-scale production of …

Combinatorial pathway optimization is an important tool in metabolic flux optimization.
Simultaneous optimization of a large number of pathway genes often leads to combinatorial …