Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Rationale: Macrophages change their phenotype and biological functions depending on the
microenvironment. In atherosclerosis, oxidative tissue damage accompanies chronic …

Abstract Models of unregulated nitric oxide (NO) diffusion do not consistently account for the
biochemistry of NO synthase (NOS)-dependent signalling in many cell systems,,. For …

Gap junctions, composed of proteins from the connexin gene family, are highly dynamic
structures that are regulated by kinase-mediated signaling pathways and interactions with …

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate
direct intercellular communication, a critical feature for the development, function, and …

Growing cancer cells effectively evade most programs of regulated cell death, particularly
apoptosis. This necessitates a search for alternative therapeutic modalities to cause cancer …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a
role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with …