Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Histones are the main components of chromatin, functioning as an instructive scaffold to
maintain chromosome structure and regulate gene expression. The dysregulation of histone …

Successful adaptation to the environment requires an accurate response to external threats
by recalling specific memories. Memory formation and recall require engram cell activity and …

Abstract Lysine-specific demethylase 1 (LSD1) targets mono-or di-methylated histone H3K4
and H3K9 as well as non-histone substrates and functions in the regulation of gene …

Alzheimer's disease (AD) is a common chronic neurodegenerative disease characterized by
cognitive learning and memory impairments, however, current treatments only provide …

Neurodevelopment can be precisely regulated by epigenetic mechanisms, including DNA
methylations, noncoding RNAs, and histone modifications. Histone methylation was a …

Tumor evolution to evade immune surveillance is a hallmark of carcinogenesis, and the
modulation of tumor immunogenicity has been a challenge to present therapeutic responses …

Heterogeneity in the etiopathology of autism spectrum disorders (ASD) limits the
development of generic remedies, requires individualistic and patient-specific research …

The central dogma of molecular genetics is defined as encoded genetic information within
DNA, transcribed into messenger RNA, which contain the instructions for protein synthesis …

The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for
axon guidance during development and are expressed by neurons in the mature brain …