PDZ domains are protein-interaction domains that are often found in multi-domain
scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large …

The morphology and molecular composition of synapses provide the structural basis for
synaptic function. This article reviews the electron microscopy of excitatory synapses on …

Excitatory synapses in the CNS release glutamate, which acts primarily on two types of
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …

The ability to visualize endogenous proteins in living neurons provides a powerful means to
interrogate neuronal structure and function. Here we generate recombinant antibody-like …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …

The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide
binding proteins (G proteins) raises the question of how a particular receptor selectively …

Abstract Ca 2+/calmodulin-dependent protein kinase II (CaMKII) is localized in the
postsynaptic density (PSD) and is necessary for LTP induction. Much has been learned …

The postsynaptic density (PSD) of central excitatory synapses plays a key role in
postsynaptic signal transduction and contains a high concentration of glutamate receptors …

Oxidative stress, an imbalance between oxidants and antioxidants, contributes to the
pathogenesis of traumatic brain injury (TBI). Oxidative neurodegeneration is a key mediator …