Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

Macroautophagy/autophagy is a conserved catabolic pathway that is vital for maintaining
cell homeostasis and promoting cell survival under stressful conditions. Dysregulation of …

The bromodomain and extra-terminal domain (BET) family inhibitors are small molecules
that target the dysregulated epigenetic readers, BRD2, BRD3, BRD4 and BRDT, at various …

The crucial role played by the oncogenic expression of TP53, stemming from mutation or
amyloid formation, in various human malignancies has been extensively studied over the …

BRAF-targeted therapies are widely used for the treatment of melanoma patients with BRAF
V600 mutations. Vemurafenib, dabrafenib as well as encorafenib have demonstrated …

As an important mechanism to maintain cellular homeostasis, autophagy exerts critical
functions via degrading misfolded proteins and damaged organelles. Recent years …

Temozolomide is an oral alkylating agent that is used as the first line treatment for
glioblastoma multiform, and in recurrent anaplastic astrocytoma, as well as having …

Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins,
dysfunctional organelles, and lipid droplets, plays a vital function in energy balance and …

Gliomas are a heterogeneous group of brain tumours with high malignancy, for which
surgical resection remains the mainstay of treatment at present. However, the overall …

Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency
and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell …