Like the first edition, this new edition emphasizes the comparative approach to
understanding vertebrate renal function. I remain convinced that this approach is of …

The blood-testis barrier (BTB) is formed by basal tight junctions between adjacent Sertoli
cells (SCs) of the seminiferous tubules and acts as a physical barrier to protect develo** …

Abstract Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role
as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO …

MATE1 (multidrug and toxin extruder 1) and OCT2 (organic cation transporter 2) play critical
roles in organic cation excretion by the human kidney. The transporter turnover rate (TOR) is …

The kinetics of solute transport shed light on the roles these processes play in cellular
physiology, and the absolute values of the kinetic parameters that quantitatively describe …

Multidrug and toxin extrusion (MATE) transporters are expressed on the luminal membrane
of renal proximal tubule cells and extrude their substrates into the luminal side of the …

Organic cation transporter 2 (OCT2) clears the blood of cationic drugs. Efforts to understand
OCT2 selectivity as a means to predict the potential of new molecular entities (NMEs) to …

Buspirone, a cationic drug, is an anxiolytic and antidepressant drug. However, whether
buspirone and its metabolites are interacted with organic cationic transporter remains …

薬物間相互作用とは, ある薬物の効果/副作用が, 同時期に併用される別の薬物によって増強/減弱
する現象である. 特に, 薬物の血中・組織中濃度の変動が起きる薬物動態学的相互作用は …

Multidrug and toxic compound extrusion (MATE) proteins are responsible for the efflux of
cationic chemicals across cell membranes. In humans, there are two orthologs …