Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

H Li, H Kim, F Xu, J Han, Q Yao, J Wang, K Pu… - Chemical Society …, 2022 - pubs.rsc.org
The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …

Hemicyanine‐based near‐infrared activatable probes for imaging and diagnosis of diseases

Z Zeng, SS Liew, X Wei, K Pu - … Chemie International Edition, 2021 - Wiley Online Library
Molecular activatable probes with near‐infrared (NIR) fluorescence play a critical role in in
vivo imaging of biomarkers for drug screening and disease diagnosis. With structural …

Advanced nanocarrier-and microneedle-based transdermal drug delivery strategies for skin diseases treatment

F Qu, R Geng, Y Liu, J Zhu - Theranostics, 2022 - pmc.ncbi.nlm.nih.gov
Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a
global burden and affecting the world economy. Skin diseases severely impact the patients' …

Thermally activated delayed fluorescence material: An emerging class of metal‐free luminophores for biomedical applications

F Fang, L Zhu, M Li, Y Song, M Sun, D Zhao… - Advanced …, 2021 - Wiley Online Library
The development of simple, efficient, and biocompatible organic luminescent molecules is of
great significance to the clinical transformation of biomaterials. In recent years, purely …

Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury

J Huang, J Li, Y Lyu, Q Miao, K Pu - Nature materials, 2019 - nature.com
Drug-induced acute kidney injury (AKI) with a high morbidity and mortality is poorly
diagnosed in hospitals and deficiently evaluated in drug discovery. Here, we report the …

Activity‐based NIR enzyme fluorescent probes for the diagnosis of tumors and image‐guided surgery

H Li, D Kim, Q Yao, H Ge, J Chung, J Fan… - Angewandte …, 2021 - Wiley Online Library
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective
edge tools for the investigation of cell biology and disease diagnosis because of their …

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

HW Liu, L Chen, C Xu, Z Li, H Zhang… - Chemical Society …, 2018 - pubs.rsc.org
Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

An activatable NIR‐II fluorescent reporter for in vivo imaging of amyloid‐β plaques

J Miao, M Miao, Y Jiang, M Zhao, Q Li… - Angewandte Chemie …, 2023 - Wiley Online Library
Fluorescence imaging in the second near‐infrared (NIR‐II) window holds great promise for
in vivo visualization of amyloid‐β (Aβ) pathology, which can facilitate characterization and …

Molecular and nanoengineering approaches towards activatable cancer immunotherapy

C Zhang, K Pu - Chemical Society Reviews, 2020 - pubs.rsc.org
Cancer immunotherapy is an emerging treatment strategy that modulates the immune
system to fight against cancer. Although several immunotherapeutic agents have been …

Organic semiconducting agents for deep‐tissue molecular imaging: second near‐infrared fluorescence, self‐luminescence, and photoacoustics

Q Miao, K Pu - Advanced materials, 2018 - Wiley Online Library
Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of
relatively low tissue penetration and poor signal‐to‐background ratio due to light scattering …