Peptide self-assembly provides an innovative strategy for not only establishing an ideal
research model to understand life phenomena but also for constructing sophisticated …

The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …

HIV can infect non-dividing cells because the viral capsid can overcome the selective barrier
of the nuclear pore complex and deliver the genome directly into the nucleus,. Remarkably …

The design and construction of synthetic cells–human‐made microcompartments that mimic
features of living cells–have experienced a real boom in the past decade. While many efforts …

RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

Cells harbour numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …

Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

The prevailing view of metazoan gene regulation is that transcription is facilitated through
the formation of static activator complexes at distal regulatory regions. Here, we employed …

Biomolecular condensates assemble in living cells through phase separation and related
phase transitions. An underappreciated feature of these dynamic molecular assemblies is …