SILAC is based on direct addition of selected stable isotope amino acids into the cell culture
medium, allowing superior quantitative analysis of the cellular proteome compared to other …

The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …

Rapid production of H2O2 is a hallmark of plant responses to diverse pathogens and plays a
crucial role in signalling downstream of various receptors that perceive immunogenic …

INTRODUCTION Aggregation of the RNA binding protein TDP-43 (TAR DNA-binding protein
43) is a common pathological hallmark shared by several age-related neurodegenerative …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

We present a sequence-tag-based search engine, Open-pFind, to identify peptides in an
ultra-large search space that includes coeluting peptides, unexpected modifications and …

Glycopeptides with unusual glycans or poor peptide backbone fragmentation in tandem
mass spectrometry are unaccounted for in typical site-specific glycoproteomics analysis and …

Structural plasticity and dynamic protein–protein interactions are critical determinants of
protein function within living systems. Quantitative chemical cross-linking with mass …

The precise and large-scale identification of intact glycopeptides is a critical step in
glycoproteomics. Owing to the complexity of glycosylation, the current overall throughput …

Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …