Melanoma develops as a result of several genetic alterations, with UV radiation often acting
as a mutagenic risk factor. Deep knowledge of the molecular signaling pathways of different …

BRAF is a member of the RAF kinase family, which acts in the ERK/MAP kinase pathway, a
signalling cascade that regulates cellular proliferation, differentiation and survival. Single …

The diagnosis of certain melanocytic proliferations remains one of the most challenging
areas in pathology. In recent times, fluorescence in situ hybridization (FISH) has emerged as …

The use of molecular diagnostic methods such as fluorescence in situ hybridization (FISH)
for challenging melanocytic neoplasms is becoming more widespread. In light of the …

The term “dysplastic nevus”(DN) implies that this nevus exists as a distinct and defined entity
of potential detriment to its host. We examine the current data, which suggest that this entity …

Cutaneous melanoma is a common and aggressive human skin cancers. Much is actually
known about the molecular mechanisms underlying melanoma pathogenesis. The aim of …

Context.—Making an accurate diagnosis for melanocytic lesions has always been
challenging for pathologists, especially when dealing with difficult-to-diagnose cases …

Several lines of evidence suggest that tumor cells show elevated activity of the NF-κB
transcription factor, a phenomenon often resulting from constitutive activity of IκB kinase β …

Dysplastic nevi have become an increasing focus clinically, with evidence that they are
associated with a higher risk of develo** melanoma. However, there still is contention …

The dysplastic nevus is a discreet histologic entity that exhibits some clinical and histologic
features overlap** with common nevi and melanoma. These overlap** features present …