Stem cell differentiation is of great interest in medical research; however, specifically and
effectively regulating stem cell differentiation is still a challenge. In addition to chemical …

Force-sensing biophysical cues in microenvironment, including extracellular matrix
performances, stretch-mediated mechanics, shear stress and flow-induced hemodynamics …

Background The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely
regulated by the blood pressure. To date, however, the molecular identity through which JG …

Brain arteriovenous malformations (bAVMs) are focal vascular lesions composed of
abnormal vascular channels without an intervening capillary network. As a result, high …

Cardiac valves ensure unidirectional blood flow through the heart, and altering their function
can result in heart failure. Flow sensing via wall shear stress and wall stretching through the …

Inactivity is a significant risk factor for cardiovascular disease. Exercise may greatly enhance
the metabolism and function of the cardiovascular system, lower several risk factors, and …

The kidneys tightly control the composition of our internal environment to maintain
homeostasis in the face of external variability. The regulation of blood volume begins in the …

Aims Mechanosensitive (MS) ion channels play a key role in heart development, physiology,
and disease. However, little is known about the molecular mechanisms of the MS non …

Hypertension is a major cardiovascular risk factor for atrial fibrillation (AF) worldwide.
However, the role of mechanical stress caused by hypertension on downregulating the L …

Fibrosis is a pathological process that occurs in various organs, characterized by excessive
deposition of extracellular matrix (ECM), leading to structural damage and, in severe cases …