Brain aging is the critical and common factor among several neurodegenerative disorders
and dementia. Cellular, biochemical and molecular studies have shown intimate links …

Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …

Mitochondrial dysfunction has been proposed to play a pivotal role in neurodegenerative
diseases, including Alzheimer's disease (AD). To address whether mitochondrial …

Profound neuronal dysfunction in the entorhinal cortex contributes to early loss of short-term
memory in Alzheimer's disease,,. Here we show broad neuroprotective effects of entorhinal …

We previously demonstrated that mitochondrial bioenergetic deficits in the female brain
accompanied reproductive senescence and was accompanied by a shift from an aerobic …

Vitamin D is an important calcium-regulating hormone with diverse functions in numerous
tissues, including the brain. Increasing evidence suggests that vitamin D may play a role in …

Although relatively neglected previously, research efforts in the past decade or so have
identified a pivotal role for glial cells in regulating neuronal function. Particular emphasis has …

Aging is accompanied by impairments in both circadian rhythmicity and long-term memory.
Although it is clear that memory performance is affected by circadian cycling, it is unknown …

The age of an experimental animal can be a critical variable, yet age matters are often
overlooked within neuroscience. Many studies make use of young animals, without …

The 'healthy cell bias of estrogen action'hypothesis examines the role that regulating
mitochondrial function and bioenergetics play in promoting neural health and the …