Signalling mechanisms and cellular functions of SUMO
ACO Vertegaal - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …
number of modifying enzymes but regulates thousands of target proteins in a dynamic …
The NCI-MATCH trial: lessons for precision oncology
Abstract The NCI-MATCH (Molecular Analysis for Therapy Choice) trial (NCT02465060) was
launched in 2015 as a genomically driven, signal-seeking precision medicine platform trial …
launched in 2015 as a genomically driven, signal-seeking precision medicine platform trial …
Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade
Immune-checkpoint blockade (ICB) therapies represent a paradigm shift in the treatment of
human cancers; however, it remains incompletely understood how tumor-reactive T cells …
human cancers; however, it remains incompletely understood how tumor-reactive T cells …
Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma
Purpose: KRAS mutation (MT) is a major oncogenic driver in pancreatic ductal
adenocarcinoma (PDAC). A small subset of PDACs harbor KRAS wild-type (WT). We aim to …
adenocarcinoma (PDAC). A small subset of PDACs harbor KRAS wild-type (WT). We aim to …
Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: a real-world study
HM Wang, CY Zhang, KC Peng, ZX Chen, JW Su… - Cell Reports …, 2023 - cell.com
Predicting the clinical response to chemotherapeutic or targeted treatment in patients with
locally advanced or metastatic lung cancer requires an accurate and affordable tool. Tumor …
locally advanced or metastatic lung cancer requires an accurate and affordable tool. Tumor …
[HTML][HTML] Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
Towards precision oncology with patient-derived xenografts
Under the selective pressure of therapy, tumours dynamically evolve multiple adaptive
mechanisms that make static interrogation of genomic alterations insufficient to guide …
mechanisms that make static interrogation of genomic alterations insufficient to guide …
The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape
D Zipinotti dos Santos, JC de Souza… - Cell Communication and …, 2023 - Springer
Background Breast cancer (BC) is the second most frequent type of cancer in the world and
most common among women, configuring a major challenge to global health. BC is a …
most common among women, configuring a major challenge to global health. BC is a …
METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …
[HTML][HTML] Crucial roles of circulating tumor cells in the metastatic cascade and tumor immune escape: biology and clinical translation
Cancer-related deaths are mainly caused by metastatic spread of tumor cells from the
primary lesion to distant sites via the blood circulation. Understanding the mechanisms of …
primary lesion to distant sites via the blood circulation. Understanding the mechanisms of …