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Regulated cell death pathways in cardiomyopathy
Heart disease is a worldwide health menace. Both intractable primary and secondary
cardiomyopathies contribute to malignant cardiac dysfunction and mortality. One of the key …
cardiomyopathies contribute to malignant cardiac dysfunction and mortality. One of the key …
Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …
modelling and drug development. In this Perspective, we reflect on the most notable …
The Imbalance of p53–Park7 Signaling Axis Induces Iron Homeostasis Dysfunction in Doxorubicin‐Challenged Cardiomyocytes
J Pan, W **ong, A Zhang, H Zhang, H Lin… - Advanced …, 2023 - Wiley Online Library
Abstract Doxorubicin (DOX)‐induced cardiotoxicity (DoIC) is a major side effect for cancer
patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in …
patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in …
Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling
Abstract Background Amorphous silica nanoparticles (SiNPs) have been gradually proven
to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a …
to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a …
Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models
In vitro modelling the complex (patho‐) physiological conditions of the heart is a major
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …
Reconstructing the heart using iPSCs: Engineering strategies and applications
Induced pluripotent stem cells (iPSCs) have emerged as a key component of cardiac tissue
engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and …
engineering, enabling studies of cardiovascular disease mechanisms, drug responses, and …
Ebselen restores peri-implantitis-induced osteogenic inhibition via suppressing BMSCs ferroptosis
Z Huang, G Chen, H Wu, X Huang, R Xu… - Experimental Cell …, 2023 - Elsevier
It is hard to reconstruct bone defects in peri-implantitis due to osteogenesis inhibited by
excessive reactive oxygen species (ROS). Ferroptosis, a recently identified regulated cell …
excessive reactive oxygen species (ROS). Ferroptosis, a recently identified regulated cell …
Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner
Neuroinflammation and microglial iron load are significant hallmarks found in several
neurodegenerative diseases. In in vitro systems, microglia preferentially upregulate the iron …
neurodegenerative diseases. In in vitro systems, microglia preferentially upregulate the iron …
[HTML][HTML] Cardiac iron metabolism during aging–Role of inflammation and proteolysis
Iron is the most abundant trace element in the human body. Since iron can switch between
its 2-valent and 3-valent form it is essential in various physiological processes such as …
its 2-valent and 3-valent form it is essential in various physiological processes such as …