The circadian clock is a widespread cellular mechanism that underlies diverse rhythmic
functions in organisms from bacteria and fungi, to plants and animals. Intense genetic …

Over the past decade, PAS domains have been identified in dozens of signal transduction
molecules and various forms have been found in animals, plants, and prokaryotes. In this …

Here we describe the cloning and characterization of a PAS domain transcription factor
termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia …

We used positional cloning to identify the circadian Clock gene in mice. Clock is a large
transcription unit with 24 exons spanning∼ 100,000 bp of DNA from which transcript classes …

Employing the clear, student-friendly style that made previous editions so popular, Insect
Physiology and Biochemistry, Fourth Edition presents an engaging and authoritative guide …

Light is a major environmental signal for circadian rhythms. We have identified and analyzed
cry, a novel Drosophila cryptochrome gene. All characterized family members are directly …

A new rhythm mutation was isolated based on its elimination of per-controlled luciferase
cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light …

Mice carrying a null mutation in the Period 1 (mPer1) gene were generated using embryonic
stem cell technology. Homozygous mPer1 mutants display a shorter circadian period with …

Cyanobacteria are the simplest organisms known to have a circadian clock. A circadian
clock gene cluster kaiABC was cloned from the cyanobacterium Synechococcus. Nineteen …

Genes are understandably crucial to physiology, morphology and biochemistry, but the idea
of genes contributing to individual differences in behaviour once seemed outrageous …