Repurposing old drugs to fight multidrug resistant cancers

J Dinić, T Efferth, AT García-Sosa, J Grahovac… - Drug Resistance …, 2020‏ - Elsevier
Overcoming multidrug resistance represents a major challenge for cancer treatment. In the
search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a …

Bisphenol a (BPA) exposure aggravates hepatic oxidative stress and inflammatory response under hypertensive milieu–impact of low dose on hepatocytes and …

M Nagarajan, GB Maadurshni, J Manivannan - Food and Chemical …, 2024‏ - Elsevier
Human exposure to the hazardous chemical, Bisphenol A (BPA), is almost ubiquitous. Due
to the prevalence of hypertension (CVD risk factor) in the aged human population, it is …

2b or not 2b: how opposing FGF receptor splice variants are blocking progress in precision oncology

RJ Epstein, LJ Tian, YF Gu - Journal of Oncology, 2021‏ - Wiley Online Library
More than ten thousand peer‐reviewed studies have assessed the role of fibroblast growth
factors (FGFs) and their receptors (FGFRs) in cancer, but few patients have yet benefited …

Al2O3 nanoparticles trigger the embryonic hepatotoxic response and potentiate TNF-α-induced apoptosis—modulatory effect of p38 MAPK and JNK inhibitors

GB Maadurshni, GK Tharani, I Udayakumar… - … Science and Pollution …, 2022‏ - Springer
Recent evidences illustrated that the release of aluminum oxide nanoparticles (Al2O3-NPs)
into the biosphere may pose risk to the environment and cause adverse effects on living …

Repurposing of thalidomide and its derivatives for the treatment of SARS‐coV‐2 infections: Hints on molecular action

L Sundaresan, S Giri, H Singh… - British Journal of …, 2021‏ - Wiley Online Library
Aims The SARS‐coV‐2 pandemic continues to cause an unprecedented global
destabilization requiring urgent attention towards drug and vaccine development …

Discovery of anticancer therapeutics: Computational chemistry and Artificial Intelligence-assisted approach

S Das, AD Talukdar, D Nath, MD Choudhury - Computational Methods in …, 2023‏ - Elsevier
Nowadays, cancer is causing a serious health issue worldwide. Due to inadequate
detection, heterogeneity in tumor formation, chemoresistance, drug resistance, and also …

In vitro and in silico biological evaluation of phthalimide derivatives as antiproliferative agents

CA Sierra-Rivera, M Kashif… - … en Ciencias Químico …, 2022‏ - medigraphic.com
Phthalimide is considered a scaffold for the development of new anticancer agents. In this
work, the antiproliferative activity of forty-three phthalimide derivatives was evaluated …