Monocytes as immune targets in arterial hypertension

P Wenzel - British journal of pharmacology, 2019‏ - Wiley Online Library
The role of myelomonocytic cells appears to be critical for the initiation, progression and
manifestation of arterial hypertension. Monocytes can induce vascular inflammation as well …

The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: Impact beyond reduced clotting

RA Alaaeddine, I AlZaim, SH Hammoud… - Clinical …, 2021‏ - portlandpress.com
Antithrombotic drugs are widely used for primary and secondary prevention, as well as
treatment of many cardiovascular disorders. Over the past few decades, major advances in …

Platelet‐derived microparticles promote endothelial cell proliferation in hypertension via miR‐142–3p

H Bao, YX Chen, K Huang, F Zhuang, M Bao… - The FASEB …, 2018‏ - Wiley Online Library
Endothelial cells (ECs) are located at the interface between flowing blood and the vessel
wall, and abnormal EC proliferation induced by pathologic environments plays an important …

α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide …

DJ Li, F Huang, M Ni, H Fu, LS Zhang… - … , and vascular biology, 2016‏ - ahajournals.org
Objective—α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has
been reported to be involved in hypertension end-organ damage. In this study, we tested the …

[HTML][HTML] TRPM8 downregulation by angiotensin II in vascular smooth muscle cells is involved in hypertension

F Huang, M Ni, JM Zhang, DJ Li… - Molecular medicine …, 2017‏ - spandidos-publications.com
Abstract Angiotensin II (Ang II)-induced injury of vascular smooth muscle cells (VSMCs)
serves an important role in hypertension and other cardiovascular disorders. Transient …

[PDF][PDF] Interruption of perivascular and perirenal adipose tissue thromboinflammation rescues prediabetic cardioautonomic and renovascular deterioration

A Al-Saidi, IF Alzaim, SH Hammoud, G Al Arab… - Clinical …, 2024‏ - portlandpress.com
The cardiovascular and renovascular complications of metabolic deterioration are
associated with localized adipose tissue dysfunction. We have previously demonstrated that …

[HTML][HTML] Comparative Analysis of the Protective Effect of Naringenin on Cardiovascular Parameters of Normotensive and Hypertensive Rats Subjected to the …

A Dada, RCV da Silva, M Zanovello, JC Moser… - Pharmaceuticals, 2024‏ - mdpi.com
Background: Cardiovascular diseases rank as the top global cause of mortality, particularly
acute myocardial infarction (MI). MI arises from the blockage of a coronary artery, which …

Implication of free fatty acids in thrombin generation and fibrinolysis in vascular inflammation in zucker rats and evolution with aging

J Lagrange, M Didelot, A Mohamadi, LA Walton… - Frontiers in …, 2017‏ - frontiersin.org
Background: The metabolic syndrome (MetS) and aging are associated with modifications in
blood coagulation factors, vascular inflammation, and increased risk of thrombosis …

Estrogen depletion modulates aortic prothrombotic signaling in normotensive and spontaneously hypertensive female rats

SB Pizzato, PB Terraciano, P Zanon, CP Kuhl… - Molecular and cellular …, 2023‏ - Elsevier
Aim In this study, we investigated how platelets and aorta contribute to the creation and
maintenance of a prothrombotic state in an experimental model of postmenopausal …

[PDF][PDF] EARLY METABOLIC DYSFUNCTION AGGRAVATES THE MOTOR AND COGNITIVE CONSEQUENCES OF CAROTID ARTERY LIGATION: IMPACT OF …

A Ghazi - 2021‏ - scholarworks.aub.edu.lb
Stroke is a predominant cause of death and disability globally. Extensive evidence support a
link between poorly controlled blood glucose, diabetes mellitus, elevated stroke risk, and …