Enhancing climate change resilience in agricultural crops
Climate change threatens global food and nutritional security through negative effects on
crop growth and agricultural productivity. Many countries have adopted ambitious climate …
crop growth and agricultural productivity. Many countries have adopted ambitious climate …
RNA methylation in plants: An overview
RNA methylation is an important post-transcriptional modification that influences gene
regulation. Over 200 different types of RNA modifications have been identified in plants. In …
regulation. Over 200 different types of RNA modifications have been identified in plants. In …
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …
FIONA1-mediated methylation of the 3'UTR of FLC affects FLC transcript levels and flowering in Arabidopsis
Adenosine bases of RNA can be transiently modified by the deposition of a methyl-group to
form N6-methyladenosine (m6A). This adenosine-methylation is an ancient process and the …
form N6-methyladenosine (m6A). This adenosine-methylation is an ancient process and the …
FLK is an mRNA m6A reader that regulates floral transition by modulating the stability and splicing of FLC in Arabidopsis
U Amara, J Hu, J Cai, H Kang - Molecular Plant, 2023 - cell.com
Abstract N 6-methyladenosine (m 6 A), which is added, removed, and interpreted by m 6 A
writers, erasers, and readers, respectively, is the most abundant modification in eukaryotic …
writers, erasers, and readers, respectively, is the most abundant modification in eukaryotic …
From computational models of the splicing code to regulatory mechanisms and therapeutic implications
Since the discovery of RNA splicing and its role in gene expression, researchers have
sought a set of rules, an algorithm or a computational model that could predict the splice …
sought a set of rules, an algorithm or a computational model that could predict the splice …
Ghost authors revealed: The structure and function of human N6‐methyladenosine RNA methyltransferases
K Breger, CN Kunkler, NJ O'Leary… - Wiley …, 2024 - Wiley Online Library
Despite the discovery of modified nucleic acids nearly 75 years ago, their biological
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …
functions are still being elucidated. N 6‐methyladenosine (m6A) is the most abundant …
Inter-species association map** links splice site evolution to METTL16 and SNRNP27K
Eukaryotic genes are interrupted by introns that are removed from transcribed RNAs by
splicing. Patterns of splicing complexity differ between species, but it is unclear how these …
splicing. Patterns of splicing complexity differ between species, but it is unclear how these …
Methyltransferase ATMETTL5 writes m6A on 18S ribosomal RNA to regulate translation in Arabidopsis
P Song, E Tian, Z Cai, X Chen, S Chen, K Yu… - New …, 2024 - Wiley Online Library
Aberrant RNA modifications can lead to dysregulated gene expression and impeded growth
in plants. Ribosomal RNA (rRNA) constitutes a substantial portion of total RNA, while the …
in plants. Ribosomal RNA (rRNA) constitutes a substantial portion of total RNA, while the …
N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing
C Wang, N Ulryck, L Herzel, N Pythoud… - Nucleic Acids …, 2023 - academic.oup.com
Modified nucleotides in non-coding RNAs, such as tRNAs and snRNAs, represent an
important layer of gene expression regulation through their ability to fine-tune mRNA …
important layer of gene expression regulation through their ability to fine-tune mRNA …