Exploring the functional and mechanistic diversity of diiron oxidases and oxygenases

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An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

TL Ng, R Rohac, AJ Mitchell, AK Boal, EP Balskus - Nature, 2019 - nature.com
Small molecules containing the N-nitroso group, such as the bacterial natural product
streptozotocin, are prominent carcinogens, and important cancer chemotherapeutics …
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SznF, a metalloenzyme employed in the biosynthesis of streptozotocin

MJ McBride, AK Boal - Encyclopedia of Inorganic and …, 2011 - Wiley Online Library
SznF is a multidomain metalloenzyme from Streptomyces achromogenes var. streptozoticus
NRRL 2697 that is responsible for N‐nitrosourea installation into the anticancer compound …
Uložit Citovat Počet citací tohoto článku: 4 Související články