An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …

Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …

Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …

Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …

Recent advances in microbial consortia present a valuable approach for expanding the
scope of metabolic engineering. Systems biology enable thorough understanding of diverse …

Actinomycetes are excellent sources for novel bioactive compounds, which serve as
potential drug candidates for antibiotics development. While industrial efforts to find and …

Rare Actinomycetes from underexplored marine environments are targeted in drug
discovery studies due to the Actinomycetes' potentially huge resource of structurally diverse …

Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …

Adaptive laboratory evolution has proven a valuable strategy for metabolic engineering.
Here, we established an experimental evolution approach for improving microbial …