Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …
[HTML][HTML] Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and-extrinsic factors
Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at
the forefront of immunotherapy for cancers of various histological types. However, such …
the forefront of immunotherapy for cancers of various histological types. However, such …
Clinical use of dendritic cells for cancer therapy
Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for
therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe …
therapeutic vaccination of patients with cancer. Dendritic cell-based immunotherapy is safe …
Dendritic cell–based immunotherapy: state of the art and beyond
KF Bol, G Schreibelt, WR Gerritsen, IJM De Vries… - Clinical cancer …, 2016 - AACR
Dendritic cell (DC) vaccination in cancer patients aims to induce or augment an effective
antitumor immune response against tumor antigens and was first explored in a clinical trial …
antitumor immune response against tumor antigens and was first explored in a clinical trial …
Systemic treatments for metastatic cutaneous melanoma
Background The prognosis of people with metastatic cutaneous melanoma, a skin cancer, is
generally poor. Recently, new classes of drugs (eg immune checkpoint inhibitors and small …
generally poor. Recently, new classes of drugs (eg immune checkpoint inhibitors and small …
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …
activation of naïve T cells. DCs' immunological properties are modulated in response to …
Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment
H Harlin, Y Meng, AC Peterson, Y Zha, M Tretiakova… - Cancer research, 2009 - AACR
Despite the frequent detection of circulating tumor antigen–specific T cells, either
spontaneously or following active immunization or adoptive transfer, immune-mediated …
spontaneously or following active immunization or adoptive transfer, immune-mediated …
Immunotherapy of cancer in 2012
JM Kirkwood, LH Butterfield, AA Tarhini… - CA: a cancer journal …, 2012 - Wiley Online Library
The immunotherapy of cancer has made significant strides in the past few years due to
improved understanding of the underlying principles of tumor biology and immunology …
improved understanding of the underlying principles of tumor biology and immunology …
Systematic review of medical treatment in melanoma: current status and future prospects
The incidence of melanoma is increasing worldwide, and the prognosis for patients with
high‐risk or advanced metastatic melanoma remains poor despite advances in the field …
high‐risk or advanced metastatic melanoma remains poor despite advances in the field …
Biomaterials for vaccine-based cancer immunotherapy
The development of therapeutic cancer vaccines as a means to generate immune reactivity
against tumors has been explored since the early discovery of tumor-specific antigens by …
against tumors has been explored since the early discovery of tumor-specific antigens by …