Colorectal cancer (CRC) is a frequent gastrointestinal malignancy with high rates of
morbidity and mortality; 85% of these tumours are proficient mismatch repair (pMMR) …

A promising future for oncology treatment has been brought about by the emergence of a
novel approach utilizing oncolytic viruses in cancer immunotherapy. Oncolytic viruses are …

Simple Summary Immune checkpoint inhibitors have revolutionized the treatment landscape
of microsatellite instable colorectal cancer. However, their efficacy is very limited in patients …

Colorectal cancer (CRC) is the third most common cause of cancer-related deaths
worldwide, and 20% of patients with CRC present at diagnosis with metastases. The …

Immunotherapy is one of the research hotspots in colorectal cancer field in recent years. The
colorectal cancer patients with mismatch repair-deficient (dMMR) or high microsatellite …

Malignant tumors frequently exploit innate immunity to evade immune surveillance. The
priming, function, and polarization of antitumor immunity fundamentally depends upon …

ABSTRACT Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology.
While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD …

Colorectal cancer (CRC) is a common malignancy which is gradually increasing in
incidence. Survival is closely associated with stage of disease, with metastatic colorectal …

结直肠癌是消化系统最常见的恶性肿瘤, 发病率在肿瘤中排第3 位, 死亡率排第2 位,
对患者的生存期和生活质量造成了严重威胁. 免疫检查点抑制剂(ICIs) 已成为错配修复缺陷或微 …

**年来, 免疫治疗在恶性肿瘤治疗方面取得了很大的进展, 已经丰富了多种恶性肿瘤的治疗模式.
结直肠癌是全球三大常见的恶性肿瘤之一, 免疫检查点抑制剂治疗对DNA …