Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review

V Soleimani, PS Delghandi, SA Moallem… - Phytotherapy …, 2019 - Wiley Online Library
Milk thistle (Silybum marianum) is a medicinal plant from the Asteraceae family. Silymarin is
the major constituent of milk thistle extract and is a mixture of some flavonolignans such as …

A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animals

R Khazaei, A Seidavi, M Bouyeh - Veterinary Medicine and …, 2022 - Wiley Online Library
One of the most valuable medicinal plants is milk thistle (Silybum marianum) or martighal.
An annual or biennial plant of the Asteraceae family and English name Milk thistle, a Matte …

Fungal endophytes as efficient sources of plant-derived bioactive compounds and their prospective applications in natural product drug discovery: Insights, avenues …

A Singh, DK Singh, RN Kharwar, JF White, SK Gond - Microorganisms, 2021 - mdpi.com
Fungal endophytes are well-established sources of biologically active natural compounds
with many producing pharmacologically valuable specific plant-derived products. This …

Cancer chemoprevention through dietary flavonoids: what's limiting?

H Amawi, CR Ashby, AK Tiwari - Chinese journal of cancer, 2017 - Springer
Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained
from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive …

[HTML][HTML] Mechanistic insights into the pharmacological significance of silymarin

K Wadhwa, R Pahwa, M Kumar, S Kumar, PC Sharma… - Molecules, 2022 - mdpi.com
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

[PDF][PDF] Reassessing bioavailability of silymarin

S Javed, K Kohli, M Ali - Alternative medicine review, 2011 - e-lactancia.org
Silymarin, a flavonolignan derived from Silybum marianum, possesses diverse
pharmacological activities, including hepatoprotective, antioxidant, anti-inflammatory …

Antioxidants in liver health

S Casas-Grajales, P Muriel - World journal of gastrointestinal …, 2015 - pmc.ncbi.nlm.nih.gov
Liver diseases are a worldwide medical problem because the liver is the principal
detoxifying organ and maintains metabolic homeostasis. The liver metabolizes various …

[HTML][HTML] Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations

Y Wang, AJ Yuan, YJ Wu, LM Wu, L Zhang - Journal of Functional Foods, 2023 - Elsevier
Silymarin, a milk thistle extract, has anti-inflammatory, immunomodulatory, anti-lipid
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …

[HTML][HTML] Antiviral activities of silymarin and derivatives

CH Liu, A Jassey, HY Hsu, LT Lin - Molecules, 2019 - mdpi.com
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-
inflammatory, and hepatoprotective functions. Recent studies have also documented the …